Defiance Homes for Sale

Welcome to Defiance, Missouri—a hidden gem nestled in the heart of St. Charles County. This charming town, with its picturesque landscapes and a close-knit community, offers a perfect blend of rural tranquility and modern conveniences. Just a stone's throw from the bustling city of St. Louis, Defiance provides residents with easy access to urban amenities while maintaining the serene lifestyle of a small town.

Defiance is renowned for its stunning natural beauty, with rolling hills, lush vineyards, and the scenic Missouri River flowing nearby. Outdoor enthusiasts will find plenty to love, from hiking and biking trails to local parks that invite picnics and family gatherings. The town's rich history is reflected in its quaint architecture and friendly atmosphere, making it an inviting place for families, retirees, and everyone in between.

For those considering a move to this enchanting area, you’ll be delighted to discover a variety of homes for sale that cater to diverse tastes and budgets. Whether you’re looking for a cozy cottage, a spacious family home, or a luxurious estate with breathtaking views, Defiance has something for everyone. Many properties boast expansive yards, perfect for gardening or entertaining, and some even feature proximity to local vineyards, making it easy to enjoy the region's renowned wine culture.

Embrace the charm of Defiance, where community spirit thrives and homes are more than just houses—they're a place to create lasting memories. Explore the current listings today and take the first step toward making this delightful town your new home!

Newest Defiance Homes for Sale

$675,000

3 Beds ⋅ 3 Baths ⋅ 26064475 MLS ⋅ ACTIVE Status

Escape the ordinary and discover your own private retreat on 4.67 beautiful acres in the heart of Defiance, Missouri! Surrounded by mature trees and picturesque scenery, this incredible property offers the perfect combination of privacy, space, and peaceful country living. With 2,760 square feet of above-grade living space, this spacious home provides plenty of room to spread out, entertain, and enjoy everyday life. Step inside to discover inviting living spaces filled with natural light, a beautifully updated kitchen featuring white cabinetry, gorgeous countertops, stainless steel appliances, and a center island perfect for gathering with family and friends. Multiple living areas offer flexibility for entertaining and relaxation, while the inviting sunroom provides the perfect setting to enjoy your morning coffee while taking in the surrounding natural beauty. Step outside onto the expansive deck and experience the serenity of your own wooded sanctuary, with nearly five acres to explore, entertain, and enjoy! Whether you're dreaming of quiet evenings under the stars, outdoor adventures, or simply escaping the hustle and bustle, this property delivers the lifestyle you've been looking for. Located in the scenic Defiance area, just minutes from the wineries, charming communities, and recreational opportunities that make Missouri wine country so special. Properties offering this much space, privacy, and natural beauty are a rare find. Come experience everything this extraordinary property has to offer!

229 Quail Run Dr, Defiance

$675,000

3 Beds ⋅ 4 Baths ⋅ 26065737 MLS ⋅ ACTIVE UNDER CONTRACT Status

This beautifully maintained 2-bedroom, 3.5-bath log home offers rustic charm, quality finishes, and modern conveniences. Soaring cathedral ceilings highlight both the main living area and primary bedroom, creating an open and inviting atmosphere. Oak hardwood flooring flows throughout most of the main-floor living space, while a spacious loft overlooking the great room features skylights with convenient remote-controlled covers. At the heart of the home, an impressive floor-to-ceiling river rock fireplace wall showcases a wood-burning stove, adding warmth and character to the space. The adjoining kitchen is well appointed with knotty alder cabinetry, a beautiful stone stove surround, stainless steel GE appliances, and a Culligan reverse osmosis water system. Convenient main-floor laundry is located just off the kitchen and includes additional storage and a utility sink. The spacious primary suite features cathedral ceilings, a walk-in closet, and a luxurious en-suite bath with a marble walk-in shower, double vanity, and classic clawfoot soaking tub. The walkout lower level expands the living space with a large additional living area, full bath, and durable vinyl plank flooring throughout. An unfinished area offers excellent potential for a third bedroom, home office, exercise room, hobby space, or additional storage. A circular driveway extends halfway around the home to the lower-level entrance, providing convenient access and additional parking. Multiple covered and screened deck areas offer plenty of opportunities to enjoy the outdoors, entertain guests, or take in the surrounding views throughout the seasons. Car enthusiasts, hobbyists, and those looking for extra storage will appreciate the attached 3-car garage, complete with a utility sink, along with a separate 2-car detached garage. This exceptional log home brings together timeless craftsmanship, thoughtful updates, versatile spaces, and abundant garage and storage options. The home is also equipped with an ADT security system with alarms on all windows and doors. Major recent updates include a new roof and water heater, both installed in 2025. This exceptional log home combines timeless craftsmanship, thoughtful updates, versatile living spaces, and abundant garage and storage options in a truly inviting setting. For added peace of mind, the home is equipped with an ADT security system with alarms on all windows and doors. Major updates include a new roof and water heater, both installed in 2025.

10 Cedar Fork Ct, Defiance

$499,900

3 Beds ⋅ 2 Baths ⋅ 26065793 MLS ⋅ ACTIVE Status

OPEN SUN. 10/18@1-2:30 Photos coming Friday, Hello, Defiance Beauty! Rare opportunity to own 6+ breathtaking acres of level land, majestic trees, abundant wildlife & peaceful seclusion in sought-after St. Charles County! Tucked away at the end of a long private drive, this lovingly maintained 3-bedroom, 2-bath ranch offers great bones, an ideal floor plan & endless potential to create your dream home! Step inside to a welcoming entry foyer with WOW-factor possibilities, a spacious family room featuring a beautiful oversized cased archway, & a large open kitchen with convenient main-floor laundry. Three generously sized bedrooms include a primary suite with its own private full bath. The full basement offers incredible possibilities for additional living space! But the REAL SHOWSTOPPER is the LAND! Picture-perfect, park-like acreage surrounds this private oasis, offering a rare combination of open, level grounds, mature trees & natural beauty. An ENORMOUS barn opens the door to endless possibilities—hobby space, equipment storage, workshop, horse stables or potential conversion to an in-law retreat or event space, subject to approvals. The fenced backyard features garden beds, a patio perfect for entertaining & the sweet serenity of country living! Lovingly cared for & offered as part of an estate, this special property is located in the highly regarded Francis Howell School District, just minutes from everyday conveniences. Whether you dream of a peaceful retreat, hobby farm or simply room to roam, this property delivers something truly special! 6+ ACRES. ENDLESS POSSIBILITIES. ONE INCREDIBLE OPPORTUNITY! Come experience this picturesque, park-like setting for yourself. This Defiance Delight won't last!

3877 Hwy D, Defiance

$1,685,000

5 Beds ⋅ 7 Baths ⋅ 26065331 MLS ⋅ ACTIVE UNDER CONTRACT Status

Set on an exceptional three-acre homesite, this distinguished residence blends timeless elegance, refined craftsmanship, and modern luxury. Hardwood floors extend throughout the home, creating a warm and cohesive foundation for its beautifully appointed interiors. At the heart of the home is a stunning, fully renovated kitchen completed in 2024, thoughtfully designed with custom inset cabinetry, exquisite marble countertops and backsplash, an integrated marble shelf, a 48-inch professional range, a statement 55-inch hood, and an expansive 72-inch refrigerator. Unlacquered brass Cremone bolts, faucets, and cabinet hardware add a sophisticated designer touch, while a built-in coffee machine and renovated butler’s pantry with abundant storage and a dedicated coffee bar elevate everyday living and entertaining. Offering five bedrooms, five full bathrooms, and two half baths, the home provides exceptional space for both intimate living and grand-scale entertaining. A convenient main-level laundry room adds everyday functionality, while the attached eight-car garage offers an extraordinary amount of space for vehicles, storage, and recreational pursuits. Significant updates provide added peace of mind, including a new roof in 2025, HVAC updates in 2024 and 2025, and a new water heater in 2025. The backyard was fully fenced in 2022 and complemented by extensive landscaping, creating a private outdoor retreat across the expansive grounds. Additional improvements include a renovated powder room and hardwood flooring in the basement in 2022, fresh interior paint throughout in 2022, new exterior doors, and exterior painting in 2023. An unfinished basement with a private entrance presents exceptional potential for future customization, whether envisioned as private guest or multigenerational living quarters, a dedicated home office, fitness studio, or additional recreational space. A rare opportunity to enjoy space, sophistication, and versatility on three picturesque acres, with thoughtfully curated finishes, substantial recent improvements, and endless possibilities to tailor the home to your lifestyle.

1177 August Lake Dr, Defiance

$549,900

4 Beds ⋅ 4 Baths ⋅ 26063364 MLS ⋅ ACTIVE Status

Welcome to 601 Callaway Ridge Drive, where spacious ranch-style living meets the relaxed lifestyle of a lake community! This inviting home offers a desirable ranch floor plan, side-entry garage, and the peace of mind of a newer roof and HVAC. Inside, you'll find comfortable living spaces filled with natural light and a welcoming kitchen with charming French country flair—creating a warm and inviting space for everyday living and gathering. The partially finished lower level adds valuable living space with an additional bedroom and full bath, offering plenty of flexibility for guests, a home office, recreation space, or extended living. Beyond the home, enjoy the lifestyle that makes Callaway Ridge special, including access to the neighborhood lake and beach. Spend your days enjoying the water, relaxing outdoors, or simply taking in the peaceful surroundings close to home. With a newer roof and HVAC, flexible living space, side-entry garage, and access to the neighborhood lake and beach, 601 Callaway Ridge offers a wonderful combination of comfort, character, and community.

601 Callaway Ridge Dr, Defiance

$624,900

4 Beds ⋅ 3 Baths ⋅ 26063474 MLS ⋅ ACTIVE Status

Discover your own retreat in Missouri wine country on approximately 8.25 scenic acres along coveted Matson Hill Road in Unincorporated St. Charles County. Surrounded by mature woods, this meticulously maintained property offers privacy, room to explore, and a connection to nature—all within reach of everyday conveniences. Deer, turkey, and birds are frequent visitors, while a private wooded path leads to a seasonal creek. For outdoor enthusiasts, the acreage also offers the opportunity for seasonal hunting on your own property. A welcoming foyer opens to formal living and dining rooms before leading to a vaulted and beamed great room anchored by a wood-burning fireplace. The spacious country kitchen features custom wood cabinetry, Corian countertops, a center island, double ovens, and a breakfast area opening to an expansive approximately 36’ x 20’ deck. Tempered glass railing preserves the woodland views—an inviting setting for morning coffee, watching wildlife, or gathering with friends. Thoughtful updates include bathrooms, flooring, windows, and doors, along with a newer water heater. Upstairs, three spacious bedrooms feature hardwood flooring. The owner’s suite includes a walk-in closet and updated bath with marble countertops, adult-height double vanities, and a tiled shower. The finished walkout lower level offers flexible space for entertaining, guests, or multigenerational living, with a sleeping area, den, kitchenette, full bath, and direct access to the fenced backyard. An oversized side-entry garage provides RV and generator hookups, workshop space, and abundant storage. A circular driveway welcomes guests, while a separate drive leads to a pole barn with electricity and a lean-to, providing space for hobbies, equipment, or a workshop. With Chandler Hill Winery adjoining the property and its entrance just a short trip down the road, spontaneous brunches, dinners, and date nights are easy to enjoy. Other nearby wineries, Matson Hill Park, the Katy Trail, and historic Daniel Boone country offer even more ways to spend time with friends and family. Wake up surrounded by trees, spend an afternoon exploring your acreage, and meet friends at a nearby winery—all from a place that brings together the comfort of home and the beauty of Missouri wine country. Schedule your private showing TODAY!

800 Matson Hill Rd, Defiance

$700,000

3 Beds ⋅ 2 Baths ⋅ 26043468 MLS ⋅ ACTIVE Status

Take a look and step back in time with this beautiful historic home in Defiance, Missouri. This home was built in 1886 and is situated on approximately 10 picturesque acres. The property blends historic character with modern comforts, offering scenic views, spacious living areas, hardwood floors, and a distinctive center-staircase design. The main level features an executive-sized living room, gourmet-style kitchen with double ovens and granite countertops, a large dining room, main-floor laundry, full bathroom, and access to a sunroom and a patio. Upstairs are three generously sized bedrooms. All bedrooms have wood floors and wood ceilings; two include stone fireplaces, and they all have access to the second story deck. The second-floor bathroom has a walk-in shower and a farm style tub, The property 4 outbuildings: a powered workshop, a beautiful red barn, a powered She Shed, and an additional old barn. With open space, mature surroundings, and plenty of room for hobbies, storage, animals, or future possibilities, this exceptional Defiance property offers a rare combination of history, charm, acreage, and country living.

1415 Hwy F, Defiance

$799,900

4 Beds ⋅ 4 Baths ⋅ 26062370 MLS ⋅ ACTIVE Status

Great opportunity in a desirable Defiance location! This home offers the chance to add your own style and build equity with some updating and a little vision. Situated on a large lot with plenty of room to create your ideal outdoor space—including the potential for a pool. The property offers a great combination of location, lot size, and upside potential, making it an excellent opportunity for an investor, first-time buyer, or someone looking to make a home their own. Located in a sought-after area of Defiance with convenient access to local amenities, wineries, restaurants, and the surrounding community. Bring your ideas and make this property your own!

104 Wolf Trail Ct, Defiance

$615,000

4 Beds ⋅ 2 Baths ⋅ 26062828 MLS ⋅ ACTIVE Status

Welcome to this spacious and thoughtfully designed 4-bedroom, 2 bath home offering numerous updates and plenty of flexible living space. The main level features a primary bedroom with an oversized walk-in closet, along with a second bedroom that could be thoughtfully reconfigured to create a luxurious primary bathroom and convenient main-floor laundry, if desired. The updated kitchen opens outside through a double slider to a wonderful screened-in porch, creating an inviting space for morning coffee or entertainment. A separate dining room provides additional space for gatherings, while the sunken den offers a cozy retreat and features a striking 3-sided fireplace shared with the great room. Upstairs are 2 additional bedrooms and a full bath, providing extra space for guests or flexible living. The finished lower level adds even more functionality with a recreation room and wet bar, plus an additional office and generous storage space. Outside, enjoy the beautiful wood timber Pergola surrounding a stamped concrete patio perfect for relaxing or entertaining around a firepit. The hot tub stays! A tuck-under garage plus a separate third garage and a shed provide excellent parking, workshop, hobby, or storage options. With updated spaces, unique architectural details, multiple entertaining areas, and plenty of opportunities to customize the layout to best fit your needs, this home offers exceptional versatility with plenty of privacy. Additional updates include a new HVAC.

4 Wolf Trail Ct, Defiance

$739,900

4 Beds ⋅ 4 Baths ⋅ 26054878 MLS ⋅ ACTIVE Status

SELLER IS OFFERING A $10,000 CREDIT to buyer at closing - can be used towards closing costs or a rate buydown! Space, Acreage & Garage Galore! Nestled on just over 3 acres in desirable Defiance, this expansive 1.5-story home offers abundant living space, updates & the flexibility you've been looking for. The beautifully updated kitchen is a standout with white shaker cabinetry, solid-surface countertops, shiplap accents, pot-filler faucet, huge center island with built-in microwave drawer & breakfast bar, plus a walk-in pantry with cabinetry, shelving, electric & a wine cubby. Brazilian wood floors flow throughout much of the main level, while the vaulted great room features a wood-burning fireplace & stylish board & batten look accent wall. Step outside to the screened porch & expansive decking—perfect for enjoying the peaceful setting, sipping a delicious beverage or dining al fresco. The main-floor primary suite features a large walk-in closet & spacious bath with solid-surface counters, separate shower, oversized oval soaking tub & marble flooring. A beautiful library with built-in bookshelves & a separate private office provide wonderful work-from-home or quiet retreat options. Main-floor laundry includes cabinets, wash sink, closet & planning desk. Rounding out the main level is a convenient & updated half bath. Upstairs offers a loft bonus space, 3 generous bedrooms and a full bath. The finished walk-out lower level includes a large family room: perfect for binging favorite shows, game night or entertaining guests. And, a flexible bonus room would make a great study, workout or hobby space. Don't miss the half bath, large storage closet and BIG unfinished utility room. Recent improvements include Hardie Board siding (2022), TRIPLE-PANE windows (2024), FOUR sliding doors (2024) & architectural roof (2021). THE GARAGE SPACE is truly exceptional: 3-car side-entry garage PLUS a 26x31 detached garage! Partial fencing is perfect for those with or wanting pets. NOT TO MISS: TWO furnaces & A/C systems AND A Wood-burning furnace * TWO water heaters—including one dedicated to the primary suite—add even more value. There is truly so much more! What a rare opportunity you must see for yourself!

2 Patrick Ln, Defiance

$7,250,000

5 Beds ⋅ 4 Baths ⋅ 26057899 MLS ⋅ ACTIVE UNDER CONTRACT Status

Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 105.4+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s built cottage exquisitely reimagined as a luxurious country residence, and STATELY early 1800’s built 68’x36’ Stone mill/outbuilding with 2 BEAUTIFUL automatic solid wood doors, floor-to-ceiling Stone fireplace, 37’+/- vaulted ceiling, kitchen, 2 half baths, & an abundant amount of storage space, AND a COMPLETELY REDONE stone chicken coop. Throughout the cottage, historic details have been carefully preserved and complemented by modern mechanical systems, conveniences, and automated security and surveillance. The home boasts 2,815+/- SqFt, 5 bedrooms, 2 full baths, with mostly original hardwood flooring throughout and a kitchen anchored by a 65 inch La Cornue Chateau Series range. The historic mill is equally remarkable. Beautifully restored and fully climate-controlled with modern HVAC systems, the mill features a catering kitchen and expansive event and entertaining spaces. It offers an extraordinary setting for private dinners, celebrations, retreats, creative pursuits, or large-scale entertaining—all without ever leaving the privacy of the estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. Beyond the residence, private acreage unfold through rolling fields, mature woods, gardens, and majestic private pathways winding throughout the estate. A dramatic boulder firepit creates an intimate destination for evenings outdoors, while even the custom chicken coop has been thoughtfully designed to complement the architecture and character of the property. Opportunities to own a tract with this combination of history, natural beauty, privacy, and location are exceptionally rare, especially with frontage on the coveted Hwy F. This isn't just land—it's a place where your family's next chapter can begin and memories can be made for generations to come. MUST SEE! Today, you have the rare opportunity to own 105.4+/- acres of beautiful land just off Highway F, conveniently located near Augusta and Defiance, with over $1,000,000 of road and infrastructure improvements completed creating multiple opportunities for building sites on the property with electric, well and septic in place. With breathtaking ridge-top views and rolling countryside, this property is the perfect setting for a private family retreat, a picturesque mini ranch, or private equestrian estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. *ALL PARTIES UNDERSTAND PROPERTY IS SUBJECT TO SURVEY AND APPROVED THROUGH CITY & ALL GOVERNMENTAL AUTHORITIES.* Seller will also consider dividing the property in different ways. Acreage sold SEPARATELY. See MLS #’s: 26053202 (LOT #1, 22+/- ACRES), 26053203 (LOT #2, 12.5+/- ACRES), 26053360 (LOT #3, 38.5+/- ACRES), & 26053204 (LOT #4, 32+/- ACRES).

2275 Hwy F, Defiance

$3,450,000

5 Beds ⋅ 4 Baths ⋅ 26053202 MLS ⋅ ACTIVE UNDER CONTRACT Status

Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 22+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s built cottage exquisitely reimagined as a luxurious country residence, and STATELY early 1800’s built 68’x36’ Stone mill/outbuilding with 2 BEAUTIFUL automatic solid wood doors, floor-to-ceiling Stone fireplace, 37’+/- vaulted ceiling, kitchen, 2 half baths, & an abundant amount of storage space, AND a COMPLETELY REDONE stone chicken coop. Throughout the cottage, historic details have been carefully preserved and complemented by modern mechanical systems, conveniences, and automated security and surveillance. The home boasts 2,815+/- SqFt, 5 bedrooms, 2 full baths, with mostly original hardwood flooring throughout and a kitchen anchored by a 65 inch La Cornue Chateau Series range. The historic mill is equally remarkable. Beautifully restored and fully climate-controlled with modern HVAC systems, the mill features a catering kitchen and expansive event and entertaining spaces. It offers an extraordinary setting for private dinners, celebrations, retreats, creative pursuits, or large-scale entertaining—all without ever leaving the privacy of the estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. Beyond the residence, private acreage unfold through rolling fields, mature woods, gardens, and majestic private pathways winding throughout the estate. A dramatic boulder firepit creates an intimate destination for evenings outdoors, while even the custom chicken coop has been thoughtfully designed to complement the architecture and character of the property. Opportunities to own a tract with this combination of history, natural beauty, privacy, and location are exceptionally rare, especially with frontage on the coveted Hwy F. This isn't just land—it's a place where your family's next chapter can begin and memories can be made for generations to come. MUST SEE! *ALL PARTIES UNDERSTAND PROPERTY IS SUBJECT TO SURVEY AND APPROVED THROUGH CITY & ALL GOVERNMENTAL AUTHORITIES.* Additional acreage FOR SALE. See MLS #’s: 26053203 (LOT #2, 12.5+/- ACRES), 26053360 (LOT #3, 38.5+/- ACRES), & 26053204 (LOT #4, 32+/- ACRES).

2275 Hwy F, Unit LOT 1, Defiance

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Listings courtesy of Mid America Regional Information Systems Internet Data Exchange as distributed by MLS GRID.

Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker of MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information. Some listings have been excluded from this website.

Defiance Homes for Sale

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